I just downloaded the 2011 today and have uninstalled, installed, and uninstalled and downloaded again, same results. I went through the 6 step process as per Brandon above with the Photo Cleaner. Same thing afterwards. Turned off Trend Micro, same thing.
I ordered PhotoDirector 2011 on 22/07/2011 and had an issue with ordering two instead of one and just received the Email today saying my Credit Card had been credited with the proper amount. So began my attempts to open it.
When I installed PhotoDirector 2011, I was not prompted to use the Activation Code. ???? Could this have anything to do with it?