I just reproduced the issue amongst a few ISO copies I have made.
First, I created the ISO images of my BluRay movies using the latest version of Blue-Cloner 4. I then mount various ISO files that are stored on my file server using Slysoft's free Virtual Clone Drive. This mounts an ISO file to have it appear as a BluRay disc to Windows. Finally, only PowerDVD 13 has issues with a few ISO copies.
The following BluRay ISO copies cause PowerDVD to lock-up during the production title screen:
Star Trek (the 2009 remake)
Star Trek 2 The Wrath of Khan
The following BluRay ISO copies play with no issue with PowerDVD13:
The Dark Knight
Batman Begins
This is using the same computer.
Finally, these same ISO copies I had made play with no issue using other BluRay player software on the same computer.
Let me know if there is any more information that you need.