With regard to multiple montors and video cards, I'm not sure there is a "normal" way to connect them, and on my system I have two HDMI switch boxes so I can independently switch monitors/video cards on the fly. The only thing I need to do is close PD before switching, and I don't have to reboot for PD to "see" the new monitor when I relaunch it.
I've also found that it's usually better to run both monitors off of the same card when editing. It's actually possible for PD's About screen to show the nVidia icon but then also show the QuickSync option on the Produce page. Running both monitors from the same card eliminates that disphoric behavior.