It depends on your source footage, the target and your personal preferences.
So do it! You can split your footage into pieces, sharpen the parts with different settings/plugins and produce them as a range. So you don't need to produce the whole clip time consuming.
Hatti
Win 10 64, i7-4790k, 32GB Ram, 256 GB SSD, SATA 2TB, SATA 4TB, NVidia GTX1080 8GB, LG 34" 4K Wide, AOC 24" 1080