I had been trying to edit videos recorded using nVIDIA's shadowplay feature, and it looks ok (not perfect, but I don't know any better way to do) when it just comes out of production. but when I upload it onto youtube manually, it loses quality in quite a drastic manner.
I have not used YouTube option built into the PD12, as it does not seem to allow hardware acceleration. The difference in production time is too great to not use hardware acceleration.